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Updated: May 25, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated
Humberto Nicastro1, Claudia R da Luz, Daniela F S Chaves
1Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School, University of São Paulo - São Paulo, SP, Brazil. nicastro@usp.br
Abstract:
The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.
