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Prevalence and risk factors of meibomian gland dysfunction: the Singapore Malay eye study
Jay J K Siak1, Louis Tong, Wan Ling Wong
1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Purpose:
To describe the prevalence and associations of meibomian gland dysfunction (MGD) in an urban Malay population in Singapore.
Methods:
Population-based cross-sectional study of 3280 (78.7% response rate) Malay persons aged 40 to 80 years, living in Singapore. MGD was defined by a slit-lamp clinical examination as either lid margin telangiectasia or meibomian gland orifice plugging in at least one eye. Participants underwent a standardized questionnaire and clinical examination, including laboratory investigations. Data were analyzed for 3271 persons.
Results:
The age-standardized prevalence of MGD was 56.3% [95% confidence interval (CI), 53.3-59.4]. A higher MGD prevalence was found in male participants across all age groups [odds ratio (OR), 1.30; 95% CI, 1.35-1.79], postmenopausal women (OR, 1.64; 95% CI, 1.19-2.33), and all participants with pinguecula (OR, 2.43; 95% CI, 2.08-2.85), high diastolic blood pressure (OR, 1.32; 95% CI, 1.08-1.62), and use of angiotensin II receptor blockers (OR, 4.02; 95% CI, 1.74-9.27).
Conclusions:
MGD was highly prevalent in this Asian population and associated with various systemic and ocular conditions.
