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Related Experiment Videos

Hormone implants and tachyphylaxis.

T Garnett1, J W Studd, A Henderson

  • 1Dulwich Hospital Menopause Clinic, East Dulwich Grove, London.

British Journal of Obstetrics and Gynaecology
|October 1, 1990
PubMed
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Women on hormone implants with very high oestradiol levels often have a history of depression or surgical menopause. These individuals may need higher doses for effective symptom management.

Area of Science:

  • Endocrinology
  • Women's Health
  • Psychiatry

Background:

  • Hormone replacement therapy (HRT) using implants is a common treatment for menopausal symptoms.
  • Supraphysiological oestradiol levels can occur with HRT, but their implications are not fully understood.
  • The premenstrual syndrome (PMS) is also sometimes treated with hormone therapy.

Purpose of the Study:

  • To investigate the characteristics of women experiencing supraphysiological serum oestradiol levels while on hormone implant therapy.
  • To determine the prevalence of psychopathology and surgical menopause in women with elevated oestradiol levels.
  • To assess if higher oestradiol levels are required for symptom control in specific patient groups.

Main Methods:

  • Retrospective review of serum oestradiol levels in 1388 women treated with hormone implants.

Related Experiment Videos

  • Analysis of patient records to identify women with oestradiol levels above 1750 pmol/l.
  • Examination of medical histories for psychiatric referrals and surgical menopause in the identified cohort.

    • Main Results:

    • 3.0% (38 out of 1388) of women had serum oestradiol levels above 1750 pmol/l.
    • Of these 38 women, 23 were treated for menopausal symptoms and 15 for PMS.
    • A significant proportion of women with supraphysiological oestradiol levels had a history of psychiatric referral for depression (11/23 for menopause, 9/15 for PMS) or had undergone surgical menopause (9/23 for menopause).

    Conclusions:

    • Women achieving supraphysiological oestradiol levels on hormone implants frequently present with a history of psychopathology or surgical menopause.
    • These findings suggest that some women may require higher oestradiol levels for adequate symptom management during HRT.
    • Further research is warranted to optimize hormone therapy regimens for women with complex medical histories.