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Updated: May 25, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Post-migration screening for active tuberculosis in Victoria, Australia
1Department of Respiratory and Sleep Disorders Medicine, Western Hospital, Footscray, Victoria, Australia. michael.flynn@wh.org.au
Setting:
Tuberculosis (TB) screening clinic.
Objective:
To determine TB prevalence at entry, screening yield and incidence in immigrants on a TB health undertaking (TBU) who were selected for post-migration screening due to an abnormal chest radiograph (CXR) in Victoria, Australia, in the years 1996-2006.
Method:
Rates of notified TB calculated from linkage of a screening programme database with the Victorian TB database.
Results:
Prevalence at entry (cases notified between arrival in Australia and 6 months after the screening registration date) was 505 per 100,000 population; yield at entry (prevalent cases detected by the screening programme) was 420/100,000, and incidence (cases notified between 6 and 12 months after screening registration date) was 160/100,000 person-years. Persons issued a TBU after applying from within Australia (on-shore) had a prevalence of 1876/100,000, seven-fold higher than those issued a TBU outside Australia (off-shore, 254/100,000). The combination of an abnormal CXR and a tuberculin skin test ≥ 15 mm carried a prevalence of notified TB of 2907/100,000.
Conclusion:
Selective post-migration screening can achieve a high yield of notified TB.
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