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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 25, 2026

Long-Term Imaging of Identified Neural Populations using Microprisms in Freely Moving and Head-Fixed Animals
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Long-Term Imaging of Identified Neural Populations using Microprisms in Freely Moving and Head-Fixed Animals

Published on: January 19, 2024

Functional imaging in freely moving animals.

Jason N D Kerr1, Axel Nimmerjahn

  • 1Network Imaging Group, Max Planck Institute for Biological Cybernetics and Bernstein Center for Computational Neuroscience Tübingen, Spemannstr. 41, 72076 Tübingen, Germany. jason@tuebingen.mpg.de

Current Opinion in Neurobiology
|January 13, 2012
PubMed
Summary
This summary is machine-generated.

Neuroscience research uses advanced optical imaging to study brain activity and animal behavior. This review covers functional cellular imaging in freely moving rodents, highlighting recent progress and applications.

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Last Updated: May 25, 2026

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Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Animal Behavior

Background:

  • Understanding brain activity and behavior is a key neuroscience goal.
  • Electrophysiology has provided sparse neural data from freely moving animals.
  • Newer methods allow comprehensive sampling of neural and glial networks.

Purpose of the Study:

  • To review progress in functional cellular imaging in freely moving rodents.
  • To discuss challenges and biological applications of these techniques.

Main Methods:

  • Optical imaging techniques are employed for cellular sampling.
  • Two main approaches include head-restrained and freely moving animal imaging.
  • Focus on developments in miniature microscope technology for freely moving subjects.

Main Results:

  • Optical imaging enables minimally invasive, comprehensive sampling of excitable cells.
  • Advances allow studying dense networks of neurons and glia during behavior.
  • Recent years show significant progress in functional cellular imaging.

Conclusions:

  • Functional cellular imaging in freely moving rodents is rapidly advancing.
  • These techniques offer new insights into brain-behavior relationships.
  • Future applications hold promise for understanding complex biological systems.