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Different pattern of carotid and myocardial changes according to left ventricular geometry in hypertensive patients

H E Park1, T-J Youn, H-K Kim

  • 1Healthcare System Gangnam Center, Seoul National University Hospital, Gyeonggi-do, Korea.

Journal of Human Hypertension
|January 13, 2012
PubMed

Insights

Left ventricular (LV) geometry impacts vascular health. Concentric LV geometry correlates with poorer carotid artery measures, while hypertrophic geometry is linked to impaired LV function in hypertensive patients.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Left ventricular (LV) hypertrophy is linked to LV function.
  • The influence of LV geometry on vascular changes is less understood.
  • Hypertension is a major risk factor for cardiovascular disease.

Purpose of the Study:

  • To investigate the relationship between LV geometry and carotid arterial function.
  • To examine how LV geometry correlates with LV function in hypertensive patients.
  • To identify discrepancies in vascular and myocardial adaptation to LV geometry.

Main Methods:

  • Prospective recruitment of 476 hypertensive patients.
  • Echocardiography and carotid ultrasound for LV geometry, LV function, and carotid parameters (IMT, strain, stiffness).
  • Categorization of LV geometry based on relative wall thickness (RWT) and LV mass index (LVMI).

Main Results:

  • Concentric LV geometry associated with increased carotid intima-media thickness (IMT), β-stiffness, and lower strain.
  • Worse LV systolic and diastolic function observed in hypertrophic geometry (lower mitral annular velocity, higher left atrial volume index, E/E').
  • IMT independently associated with RWT; myocardial function independently associated with LVMI.

Conclusions:

  • Carotid arterial function and IMT are worse in concentric LV geometry.
  • LV systolic and diastolic function are impaired in hypertrophic LV geometry.
  • Suggests a discrepancy between carotid arterial and LV function adaptation in hypertensive patients.

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