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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
Live cell luminescence imaging as a function of delivery mechanism
Xiaohe Tian1, Martin R Gill, Irene Cantón
1Department of Biomedical Science, The University of Sheffield, Sheffield S10 7TN, UK.
Chembiochem : a European Journal of Chemical Biology
|January 13, 2012
Abstract:
Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH-sensitive polymersome vector. This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties.
