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Primary hyperparathyroidism and celiac disease: a population-based cohort study.
Jonas F Ludvigsson1, Olle Kämpe, Benjamin Lebwohl
1Department of Pediatrics, Örebro University Hospital, 701 85 Örebro, Sweden. jonasludvigsson@yahoo.com
The Journal of Clinical Endocrinology and Metabolism
|January 13, 2012
Summary
Patients with celiac disease (CD) have a nearly double risk of developing primary hyperparathyroidism (PHPT). However, the absolute risk of PHPT is small and this increased risk diminishes after five years.
Area of Science:
- Endocrinology
- Gastroenterology
- Epidemiology
Background:
- Celiac disease (CD) is associated with endocrine disorders like type 1 diabetes and thyroid issues.
- The link between celiac disease and primary hyperparathyroidism (PHPT) is not well understood.
Purpose of the Study:
- To investigate the risk of developing PHPT in individuals diagnosed with celiac disease.
Main Methods:
- A matched cohort study in Sweden included 17,121 adult CD patients and 85,166 controls.
- Cox regression analysis was used to calculate hazard ratios (HR) for PHPT.
- Data on PHPT diagnoses were obtained from national healthcare registers.
Main Results:
- Patients with CD had a significantly higher risk of PHPT (HR=1.91).
- The absolute risk of PHPT in CD patients was 42 per 100,000 person-years.
- The elevated risk for PHPT was observed within the first five years of follow-up, with no significant increase thereafter.
Conclusions:
- Celiac disease patients face an increased risk of primary hyperparathyroidism.
- The overall absolute risk of PHPT is low.
- The excess risk of PHPT associated with CD is temporary, disappearing after five years.
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