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Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Stem Cell Therapy for Tissue Regeneration

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Whole Body Regeneration

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Related Experiment Video

Updated: May 25, 2026

Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

VEGF: Potential therapy for renal regeneration.

Alejandro R Chade

F1000 Medicine Reports

|January 13, 2012

Summary

Vascular endothelial growth factor (VEGF) administration may protect the kidneys from injury by stimulating microvascular repair. This targeted approach could be a novel therapy for chronic kidney disease.

Area of Science:

Nephrology
Cardiovascular Biology
Angiogenesis Research

Background:

Vascular endothelial growth factor (VEGF) is crucial for blood vessel formation and survival.
VEGF's dual role: anti-VEGF therapies target tumors, but can cause hypertension and kidney damage.
VEGF administration shows promise in repairing ischemic tissues like the heart and kidneys.

Purpose of the Study:

To explore intra-renal VEGF administration for preserving renal microcirculation.
To investigate mechanisms for decreasing progressive renal injury in chronic renovascular disease.
To evaluate VEGF as a potential therapeutic strategy for kidney protection.

Main Methods:

This is a commentary discussing existing clinical and experimental evidence.

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Intravascular Delivery of Biologics to the Rat Kidney

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Focuses on the potential mechanisms of intra-renal VEGF delivery.

Reviews the role of VEGF in microvascular repair and renal function.

Main Results:

Targeted VEGF administration may stimulate microvascular proliferation and repair within the kidney.
This approach has the potential to mitigate collateral damage from anti-VEGF therapies.
VEGF delivery could protect against progressive renal injury in chronic conditions.

Conclusions:

Intra-renal VEGF administration is a potential novel intervention for renal protection.
It may serve as a standalone or co-adjuvant therapy for chronic kidney disease.
Targeted VEGF delivery offers a strategy to preserve renal function in renovascular disease.