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Related Concept Videos

Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Diversity of Protists IV01:27

Diversity of Protists IV

Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
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Related Experiment Video

Updated: May 25, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites
10:16

Generating Genetically Modified Plasmodium berghei Sporozoites

Published on: May 5, 2023

Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

Carina S S Gomes-Santos1, Maurice A Itoe, Cristina Afonso

  • 1Malaria Unit, Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisboa, Portugal.

Plos One
|January 13, 2012
PubMed
Summary

Hepatocyte actin reorganization occurs around developing Plasmodium parasites, influenced by gelsolin. This dynamic process may help eliminate malaria parasites during liver-stage development.

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Area of Science:

  • Cell Biology
  • Parasitology
  • Immunology

Background:

  • Plasmodium sporozoites infect hepatocytes, initiating malaria liver-stage development within a parasitophorous vacuole.
  • The molecular interactions at the Plasmodium-host hepatocyte interface are not well understood.
  • Hepatocyte cytoskeletal dynamics during parasite development remain largely uncharacterized.

Purpose of the Study:

  • To investigate hepatocyte cytoskeletal rearrangements during Plasmodium berghei infection.
  • To determine the role of host actin dynamics in parasite development and elimination.

Main Methods:

  • Live cell imaging of Plasmodium berghei-infected human hepatoma cells.
  • Analysis of actin reorganization patterns and their temporal dynamics.
  • Investigation of the involvement of gelsolin in actin remodeling.

Main Results:

  • Significant hepatocyte actin reorganization was observed around developing Plasmodium parasites.
  • Actin remodeling peaked between 10 to 16 hours post-infection.
  • Gelsolin, an actin-severing protein, was found to be crucial for these actin reorganization events.

Conclusions:

  • Hepatocyte actin dynamics are highly responsive to Plasmodium infection.
  • The host cytoskeleton, particularly involving gelsolin, plays a role in managing parasite development.
  • These findings suggest a potential host defense mechanism against Plasmodium during the liver stage.