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Published on: April 13, 2022
Stem cells from oral niches: a review
Guido Giordano1, Gerardo La Monaca, Susanna Annibali
1Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome, Rome, Italy.
Annali Di Stomatologia
|January 13, 2012
Summary
Dental stem cell research, particularly from dental pulp, shows significant promise for regenerating bone and teeth. Studies from oral niches have rapidly increased since 2000, highlighting the potential of these cells.
Area of Science:
- Regenerative medicine
- Dental research
- Stem cell biology
Background:
- Stem cell research is a rapidly advancing field with significant potential in dentistry.
- Studies aim to regenerate bone and teeth using stem cells derived from oral tissues.
- Significant expectations surround early findings in dental stem cell applications.
Purpose of the Study:
- To review the current state of stem cell research in dentistry.
- To provide an overview of advancements in dental stem cell applications.
- To highlight key research areas and findings in the field.
Main Methods:
- A comprehensive web-based literature search was conducted on MEDLINE (PubMed).
- Keywords included 'stem cells from human exfoliated deciduous teeth,' 'periodontal ligament stem cells,' 'stem cell apical papilla,' and 'dental pulp stem cells.'
- A chronological review of selected papers was performed for each keyword to track research development.
Main Results:
- Research on oral stem cells has shown exponential growth since 2000.
- The review analyzed approximately 180 articles, with a focus on the last five years.
- Dental pulp stem cells, from both adult and deciduous teeth, emerged as a highly valuable source.
Conclusions:
- Dental pulp stem cells are identified as a potent source for regenerative therapies.
- The pluripotential nature of dental pulp stem cells underpins their therapeutic value.
- Continued research in dental stem cells holds promise for future oral tissue regeneration.
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