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CYFRA 21-1 as a tool for distant metastasis detection in lung cancer
J L Cabrera-Alarcon1, A Carrillo-Vico, J D Santotoribio
1Department of Clinical Biochemistry, Virgen del Rocio University Hospital, IBIS/CSIC/University of Seville, Avenida Manuel Siurot, Seville, Spain.
Background:
A study to analyse tumor markers (CEA, CA125, CA15.3, CA19.9, CYFRA 21-1, and NSE) for metastasis detection in lung cancer patients.
Methods:
Serum tumor markers from 73 lung cancer patients were measured before they were diagnosed. After lung cancer diagnosis, tumor markers were analyzed for the detection of distant metastases.
Results:
In NSCLC patients CYFRA 21-1 and NSE showed differences between stage IV and any of the other stages, p < 0.05. The accuracy for metastasis detection was AUC = 81.5 % for CYFRA 21-1 and AUC = 78.6 % for < 0.05) were independent predictors for metastasis presence. No tumor marker showed significant differences according to stages in SCLC patients.
Conclusions:
CYFRA 21-1 could be used as a screening tool for metastasis detection in lung cancer patients without symptoms of metastasis as well as CYFRA 21-1 and NSE in NSCLC patients.
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