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Hyperhemolysis syndrome complicating pregnancy in homozygous δβ-thalassemia

Joseph Mechery1, Kehinde Abidogun, Fiona Crosfill

  • 1Department of Obstetrics and Gynaecology, Royal Preston Hospital, Preston, Lancashire, UK. jmechery@nhs.net

Hemoglobin
|January 14, 2012
PubMed

Hyperhemolysis syndrome in patients with sickle cell disease who are given compatible blood has been well described in the literature but a similar condition complicating pregnancy in β-thalassemia (β-thal) has not been reported. Pregnancy itself or continuation of blood transfusions can further exacerbate the condition which may become life-threatening. The exact mechanism of hyperhemolysis is not well understood. A bystander hemolysis mechanism has been proposed. Treatment with steroids, immunoglobulins and cyclosporin can be life saving.

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