Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hydrogel biomaterials to support and guide vascularization.

Progress in biomedical engineering (Bristol, England)·2025

Same author

Considerations to Better Meet the Needs of People Living With Diabetes While in Prison or Detention.

Diabetes spectrum : a publication of the American Diabetes Association·2024

Same author

A Pragmatic Rethinking of Glucose Monitoring for the Incarcerated.

Diabetes spectrum : a publication of the American Diabetes Association·2024

Same author

Detection of fluorescent protein mechanical switching in cellulo.

Cell reports methods·2024

Same author

Neurogenic Cell Behavior in 3D Culture Enhanced Within a Highly Compliant Synthetic Hydrogel Platform Formed via Competitive Crosslinking.

Cellular and molecular bioengineering·2024

Same author

Antibiotic exposure is associated with decreased risk of psychiatric disorders.

Frontiers in pharmacology·2024

Search research articles

Related Experiment Video

Updated: May 25, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Biofunctional materials for directing vascular development.

Jennifer E Saik¹, Melissa K McHale, Jennifer L West

¹Department of Bioengineering, Rice University, Houston, TX 77005, USA.

Current Vascular Pharmacology

|January 14, 2012

Summary

Engineered tissues need blood vessels for success. This review explores how smart biomaterials and growth factors can create functional vascular networks in tissue engineering.

More Related Videos

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Related Experiment Videos

Last Updated: May 25, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Area of Science:

Biomaterials Science
Tissue Engineering
Vascular Biology

Background:

Engineered tissue constructs often fail due to insufficient vascularization.
Developing functional blood vessel networks is critical for tissue survival and integration.
Current strategies aim to mimic natural vascularization processes.

Purpose of the Study:

To review rationally designed materials for supporting neovessel formation.
To discuss biomaterial scaffolds as growth factor delivery systems.
To explore strategies for mature vascular network development in engineered tissues.

Main Methods:

Review of literature on biomaterial scaffolds and vascularization.
Analysis of strategies for growth factor delivery.
Examination of methods to direct cellular responses for vascular network formation.

Main Results:

Rationally designed materials can support functional neovessel formation and stabilization.
Biomaterial scaffolds can be engineered for controlled growth factor release.
Functional enhancement strategies are key to directing cellular responses for vascularization.

Conclusions:

Advanced biomaterials are essential for overcoming vascularization limitations in tissue engineering.
Tailored material design and growth factor delivery are crucial for creating mature vascular networks.
Further research into material-cell interactions will advance functional tissue regeneration.