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Related Experiment Video

Updated: May 25, 2026

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Published on: December 5, 2020

Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.

Jaydev K Dave¹, Valgerdur G Halldorsdottir, John R Eisenbrey

¹Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

JACC. Cardiovascular Imaging

|January 14, 2012

Summary

This summary is machine-generated.

This study shows ultrasound microbubbles can noninvasively measure left ventricular (LV) pressures. This new method offers a potential way to monitor cardiac function without invasive procedures.

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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Area of Science:

Cardiovascular Imaging
Biomedical Ultrasound
Medical Physics

Background:

Accurate measurement of left ventricular (LV) pressures is crucial for diagnosing and managing cardiovascular diseases.
Current methods for measuring LV pressures are often invasive, carrying risks and limitations.

Purpose of the Study:

To develop and validate a novel noninvasive technique for quantifying LV pressures.
To utilize subharmonic emissions from microbubbles for pressure estimation.

Main Methods:

An ultrasound scanner in pulse inversion grayscale mode was employed.
Radiofrequency data were acquired from the aorta and/or LV during Sonazoid infusion.
Subharmonic data were extracted, processed, and calibrated against aortic pressure to estimate LV pressures.

Main Results:

LV pressure estimation using a specific aortic calibration factor yielded errors between 0.19 and 2.50 mm Hg.
Using a mean aortic calibration factor resulted in higher errors, ranging from 0.64 to 8.98 mm Hg.

Conclusions:

Subharmonic emissions from ultrasound contrast agents demonstrate potential for noninvasive LV pressure monitoring.
This technique offers a promising alternative to invasive pressure measurements in clinical settings.