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A population-based study on the association between gastric ulcers and erectile dysfunction in Taiwan
Joseph J Keller1, Hsiao-Yu Lin, Shiu-Dong Chung
1School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, Taiwan.
The Journal of Sexual Medicine
|January 14, 2012
Summary
This study found a link between gastric ulcers (GUs) and erectile dysfunction (ED). Men with a history of GU were more likely to be diagnosed with ED, especially younger individuals.
Area of Science:
- Urology
- Gastroenterology
- Epidemiology
Background:
- Erectile dysfunction (ED) and cardiovascular disease share endothelial dysfunction as a common mechanism.
- Limited research has explored the link between ED and gastric ulcers (GUs) via endothelial dysfunction.
Purpose of the Study:
- To investigate the association between erectile dysfunction (ED) and gastric ulcers (GUs).
Main Methods:
- A population-based case-control study using Taiwan's Longitudinal Health Insurance Database 2000.
- Included 6,906 patients diagnosed with ED (cases) and 20,718 controls.
- Conditional logistic regression analyzed the association between ED and prior GU diagnoses.
Main Results:
- 14% of subjects had a prior GU diagnosis.
- Cases with ED were significantly more likely to have a prior GU diagnosis than controls (OR=1.65, 95% CI=1.53-1.77), after adjusting for comorbidities and SES.
- The association was strongest in the youngest age group (18-29 years) of ED patients.
Conclusions:
- A positive association exists between a history of gastric ulcers (GUs) and a subsequent diagnosis of erectile dysfunction (ED).
- This finding highlights a potential shared pathway or risk factor between GU and ED.
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