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Gastrointestinal bleeding in infantile hemangioma: a complication of segmental, rather than multifocal, infantile
Beth A Drolet1, Elena Pope, Anna M Juern
1Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA. bdrolet@mcw.edu
Insights
Facial segmental hemangiomas in infants may indicate a risk of gastrointestinal bleeding. This association suggests a potential link between these conditions, requiring further investigation for early diagnosis and management.
Area of Science:
- Pediatric Gastroenterology
- Dermatology
- Vascular Malformations
Background:
- Infantile hemangiomas are common benign vascular tumors in infants.
- Segmental patterns of infantile hemangiomas may be associated with specific syndromes and complications.
- Gastrointestinal bleeding is a rare but serious complication in infants with hemangiomas.
Observation:
- A multicenter retrospective case series identified ten female infants with infantile hemangiomas.
- Nine of the ten infants presented with facial segmental hemangiomas.
- Nine infants experienced severe gastrointestinal bleeding requiring transfusions, often originating from the small intestine.
Findings:
- Facial segmental hemangiomas were associated with a high incidence of severe gastrointestinal bleeding.
- The hemangiomas often involved the small intestine within the superior mesenteric artery distribution.
- Treatment for gastrointestinal bleeding required multiple interventions, including medications and surgery.
Implications:
- The presence of a facial segmental hemangioma should raise suspicion for associated gastrointestinal bleeding.
- Early recognition and management of gastrointestinal bleeding in infants with segmental hemangiomas are crucial.
- This association may warrant further investigation into underlying pathogenetic mechanisms and diagnostic approaches.
Objective:
To highlight an association of facial segmental hemangiomas with gastrointestinal bleeding in infants with infantile hemangiomas.
Study Design:
We conducted a multicenter retrospective case series study.
Results:
Ten female patients met study inclusion criteria; 8 were Caucasian, 9 had a facial segmental hemangioma, and 9 cases met the diagnostic criteria for definitive posterior fossa malformations, hemangioma, arterial lesions, cardiac anomalies/coarctation of the aorta and eye abnormalities syndrome with abnormalities of the aorta and cerebral arteriopathy. Severe gastrointestinal bleeding requiring blood transfusion occurred in 9 cases, with age at presentation of gastrointestinal bleeding ranging from 8 days to 6 months. When detected, the location of the hemangioma in the small intestine was in the distribution of the superior mesenteric artery. More than one agent was required to control the gastrointestinal bleeding, including oral or intravenous steroids, vincristine, oral propranolol, interferon, and resection of the small intestine. All cases needed ongoing support care with red blood cell transfusions.
Conclusions:
Gastrointestinal bleeding is a rare complication of true infantile hemangioma. The segmental pattern of the cutaneous hemangioma associated with gastrointestinal bleeding should suggest a segmental infantile hemangioma of the lower gastrointestinal tract.
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