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Updated: May 25, 2026
Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
[Bronchiolo-alveolar carcinoma and lung transplantation]
V Avrillon1, F Philit, L Chalabreysse
1Services de pneumologie et de chirurgie thoracique, centre de biologie Est, centre de pathologie Est, hôpital Louis-Pradel, hospices civils de Lyon, 28, avenue Doyen-Delépine, 69677 Bron, France.
Introduction:
Bronchiolo-alveolar carcinoma is a controversial indication for lung transplantation because of the risk of recurrence. We report three cases and propose some risk factors for recurrence.
Case Reports:
Our study concerns three patients transplanted at the Louis-Pradel Hospital between 1991 and 2010. The first patient relapsed 86 months after transplantation, benefited from surgical treatment, then died of renal failure. A second patient died of infection, without recurrence, 72 months after transplantation. The third had an early recurrence at 7 months and died 27 months after transplantation. The risk factors for recurrence appear to be: clinically "aggressive" presentation and histological stromal pulmonary invasion by the carcinoma.
Conclusion:
Diffuse bronchiolo-alveolar carcinoma is a possible indication of lung transplantation. The risk of recurrence imposes some requirements: a precise histological diagnosis and a slow clinical course.
