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Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
Reduction of fluoroquinolone use is associated with a decrease in methicillin-resistant Staphylococcus aureus and
Matthieu Lafaurie1, Raphael Porcher, Jean-Luc Donay
1Infectious Diseases Intervention Unit (U2i), Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010, Paris, France. matthieu.lafaurie@sls.aphp.fr
The Journal of Antimicrobial Chemotherapy
|January 14, 2012
Summary
Reducing fluoroquinolone use significantly decreased rates of fluoroquinolone-resistant Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA). This 4-year study demonstrates the sustained impact of antibiotic stewardship programs on combating resistant bacteria.
Area of Science:
- Infectious Diseases
- Antimicrobial Resistance
- Hospital Epidemiology
Background:
- High rates of MRSA and fluoroquinolone-resistant P. aeruginosa are linked to fluoroquinolone overuse.
- Antibiotic stewardship programs are crucial for controlling resistant pathogens.
Purpose of the Study:
- To analyze long-term surveillance data on MRSA and fluoroquinolone-resistant P. aeruginosa rates.
- To correlate these rates with antibiotic consumption following a fluoroquinolone reduction program.
Main Methods:
- An interrupted time series/quasi-experimental study design.
- Data collected over three periods: pre-intervention, intervention, and post-intervention (2000-2010).
- Segmented regression analyses used to assess intervention impact on bacterial resistance and fluoroquinolone consumption.
Main Results:
- Fluoroquinolone consumption decreased by 29.1 DDD/1000 PD during the intervention.
- A sustained reduction in fluoroquinolone use of -0.95 DDD/1000 PD/month post-intervention.
- Fluoroquinolone-resistant P. aeruginosa rates decreased from 42% to 26% post-intervention.
- MRSA rates decreased from 27% to 21% during the intervention period.
Conclusions:
- A fluoroquinolone control program effectively reduced antibiotic use.
- Significant decreases in fluoroquinolone-resistant P. aeruginosa and MRSA rates were observed.
- The study highlights the sustained impact of antimicrobial stewardship over 4 years.
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