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Published on: June 16, 2014

Resistin level in coronary artery disease and heart failure: the central role of kidney function

Samuele Baldasseroni1, Edoardo Mannucci, Claudia Di Serio

  • 1Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, Florence, Italy. pesine@libero.it

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|January 14, 2012
PubMed

Insights

Resistin levels increase with worsening heart failure in coronary artery disease (CAD) patients. Reduced kidney function, not just heart dysfunction, significantly predicts higher resistin levels in CAD patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nephrology

Background:

  • Resistin, an adipokine, has been implicated in cardiovascular disease.
  • Its role in coronary artery disease (CAD) and chronic heart failure (CHF) requires further elucidation.
  • Understanding resistin's predictors is crucial for managing these conditions.

Purpose of the Study:

  • To investigate resistin levels in patients with CAD, stratified by the presence and severity of heart failure.
  • To identify independent predictors of plasma resistin levels in this patient cohort.

Main Methods:

  • 107 outpatients with CAD were categorized into three groups based on left-ventricular function and heart failure symptoms.
  • Plasma resistin concentrations were quantified using enzyme-linked immunosorbent assay (ELISA).
  • Multivariable analysis was employed to determine independent predictors of resistin levels.

Main Results:

  • Resistin levels showed a progressive increase across the groups, from CAD without dysfunction to CAD with overt heart failure.
  • A statistically significant elevation in resistin was observed in patients with overt heart failure compared to other groups (P=0.001).
  • Estimated glomerular filtration rate (eGFR) emerged as the strongest independent predictor of plasma resistin (P<0.001), indicating kidney function decline as a primary driver.

Conclusions:

  • The study confirms elevated resistin levels in patients with chronic heart failure.
  • The increase in resistin appears predominantly mediated by impaired kidney function rather than solely by the severity of ventricular dysfunction.
  • These findings highlight the interplay between renal function and resistin in the context of CAD and heart failure.
Abstract

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