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Plasma adrenomedullin concentration in dogs with myxomatous mitral valvular disease

Nobuyuki Kanno1, Kazushi Asano, Kenji Teshima

  • 1Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. nkanno@cc.miyazaki-u.ac.jp

The Journal of Veterinary Medical Science
|January 14, 2012
PubMed

Insights

Plasma Adrenomedullin (AM) is elevated in dogs with myxomatous mitral valvular disease (MMVD), correlating with heart failure severity. Higher AM levels may serve as a diagnostic marker for canine heart disease.

Area of Science:

  • Veterinary Cardiology
  • Endocrinology
  • Biomarker Discovery

Background:

  • Adrenomedullin (AM) is a peptide hormone with known cardiovascular regulatory functions.
  • Myxomatous mitral valvular disease (MMVD) is a common cardiac condition in dogs.
  • Understanding biomarkers for MMVD is crucial for early diagnosis and management.

Purpose of the Study:

  • To measure plasma AM concentrations in dogs with and without MMVD.
  • To investigate the relationship between plasma AM levels and MMVD severity.
  • To explore correlations between AM, natriuretic peptides, and echocardiographic findings.

Main Methods:

  • Plasma AM concentrations were measured in 31 healthy dogs and 57 dogs with MMVD.
  • Echocardiographic data and International Small Animal Cardiac Health Council (ISACHC) classifications were recorded.
  • Statistical analyses, including receiver operating characteristic (ROC) curve analysis, were performed.

Main Results:

  • Dogs with MMVD exhibited significantly higher plasma AM concentrations than healthy controls.
  • Plasma AM levels increased progressively with worsening heart failure (ISACHC classes).
  • A cutoff value of 30.5 fmol/ml demonstrated 87.1% sensitivity and 82.5% specificity for congestive heart failure.

Conclusions:

  • Plasma AM is a potential diagnostic biomarker for canine MMVD.
  • AM concentrations correlate with disease severity and echocardiographic parameters.
  • AM may play a role in the pathophysiology of MMVD alongside natriuretic peptides.

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