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Correlation of apparent diffusion coefficient at 3T with prognostic parameters of retinoblastoma
A A K Abdel Razek1, S Elkhamary, S Al-Mesfer
1Diagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura, Egypt, 13551. arazek@mans.edu.eg
Insights
Apparent diffusion coefficient (ADC) values from MRI correlate with retinoblastoma's aggressiveness. Lower ADC values indicate poorer differentiation, larger size, and optic nerve invasion, aiding noninvasive prognosis.
Area of Science:
- Radiology
- Oncology
- Ophthalmology
Background:
- Retinoblastoma prognosis relies on pathological parameters.
- Accurate prognostic markers are crucial for treatment planning.
Purpose of the Study:
- To correlate apparent diffusion coefficient (ADC) values obtained via 3 Tesla (3T) MRI with established prognostic parameters in retinoblastoma.
- To evaluate the potential of ADC values as a noninvasive prognostic tool.
Main Methods:
- Seventy-two children with retinoblastoma underwent pretreatment diffusion-weighted MRI at 3T.
- ADC values were calculated and correlated with histopathologic findings: differentiation, tumor size, bilaterality, choroidal invasion, and optic nerve extension.
Main Results:
- Mean ADC value was 0.49 ± 0.12 × 10(-3) mm(2)/s.
- ADC values significantly differed based on tumor differentiation, size, and bilaterality (P < .015).
- Lower ADC values correlated with poor differentiation (r=0.87), larger size (r=-0.68), and optic nerve invasion (P=.003).
Conclusions:
- ADC values show significant correlation with key prognostic indicators in retinoblastoma.
- ADC may serve as a valuable noninvasive biomarker for assessing retinoblastoma prognosis.
Background And Purpose:
Pathologic prognostic parameters for retinoblastoma have been defined. Our purpose was to correlate ADC values at 3T with prognostic parameters of retinoblastoma.
Materials And Methods:
This study included 72 children (30 boys and 42 girls, mean age 19 ± 2.6 months) with retinoblastoma. Pretreatment diffusion-weighted MR imaging was performed on a 3T scanner with b factors of 0, 500, and 1000 seconds/mm(2). ADC values were calculated and pathologic specimens were analyzed. ADC values of the tumors were then correlated with prognostic parameters, including degree of histologic differentiation, tumor size, bilaterality, choroidal invasion, and optic nerve extension.
Results:
The mean ADC value of retinoblastoma was 0.49 ± 0.12 × 10(-3) mm(2)/s. The ADC values of well- and moderately differentiated tumors were significantly different (P = .007) from poorly and undifferentiated retinoblastoma. There was also a significant difference in the ADC value among small, medium, and large tumors (P = .015), as well as between unilateral and bilateral retinoblastoma (P = .001), and this was independent of the degree of differentiation. The ADC value was also significantly lower (P = .003) when optic nerve invasion was present. There was no correlation of ADC value with growth pattern or choroidal invasion (P = .640 and 0.661, respectively). The ADC value of retinoblastoma was well correlated with the degree of differentiation of the tumor (r = 0.87, P = .007) and inversely correlated with the size of the tumor (r = -0.68, P = .015).
Conclusions:
ADC correlated with some of the accepted parameters of poor prognosis for retinoblastoma and may serve as a noninvasive prognostic parameter for assessment of newly diagnosed retinoblastoma.
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