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[Proto-oncogenes activation in human solid tumors]
1U 119 INSERM, Marseille, France.
Bulletin Du Cancer
|January 1, 1990
Abstract:
Genetic alterations in solid human tumors occur in several groups of genes, one of which contains the proto-oncogenes. These genes are involved in the control of cell proliferation and become activated in oncogenes by various mechanisms. These activations are reviewed herein.
Insights
Genetic alterations in solid tumors involve proto-oncogenes, which control cell proliferation. These genes can become activated oncogenes through various mechanisms, as reviewed in this study.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Solid tumors exhibit genetic alterations impacting key cellular pathways.
- Proto-oncogenes play a critical role in regulating cell growth and division.
- Understanding oncogene activation is crucial for cancer research.
Purpose:
- To review the mechanisms by which proto-oncogenes are activated into oncogenes.
- To provide an overview of genetic alterations in solid human tumors related to proto-oncogenes.
Summary:
- Genetic alterations are common in solid tumors, affecting gene groups including proto-oncogenes.
- Proto-oncogenes regulate cell proliferation and their activation into oncogenes occurs via multiple mechanisms.
- This review consolidates current knowledge on these proto-oncogene activations.
Impact:
- Provides a foundational understanding of oncogene activation in solid tumors.
- Highlights the significance of proto-oncogenes in cancer development.
- Serves as a reference for researchers studying genetic alterations in cancer.