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[Proto-oncogenes activation in human solid tumors].

D Birnbaum1, O de Lapeyrière

  • 1U 119 INSERM, Marseille, France.

Bulletin Du Cancer
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Genetic alterations in solid tumors involve proto-oncogenes, which control cell proliferation. These genes can become activated oncogenes through various mechanisms, as reviewed in this study.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Solid tumors exhibit genetic alterations impacting key cellular pathways.
  • Proto-oncogenes play a critical role in regulating cell growth and division.
  • Understanding oncogene activation is crucial for cancer research.

Purpose:

  • To review the mechanisms by which proto-oncogenes are activated into oncogenes.
  • To provide an overview of genetic alterations in solid human tumors related to proto-oncogenes.

Summary:

  • Genetic alterations are common in solid tumors, affecting gene groups including proto-oncogenes.
  • Proto-oncogenes regulate cell proliferation and their activation into oncogenes occurs via multiple mechanisms.
  • This review consolidates current knowledge on these proto-oncogene activations.

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Impact:

  • Provides a foundational understanding of oncogene activation in solid tumors.
  • Highlights the significance of proto-oncogenes in cancer development.
  • Serves as a reference for researchers studying genetic alterations in cancer.