Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation
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Updated: May 25, 2026

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Oksana A Shlobin1, Steven D Nathan
1Advanced Lung Disease and Transplant Program, Dept of Medicine, Inova Fairfax Hospital, Falls Church, VA 22042, USA. oksana.shlobin@inova.org
Abstract:
Sarcoidosis is not only a multisystem, but also a multinational disease that is prevalent throughout the world, including Europe, the USA and Japan. Lung involvement in sarcoidosis is seemingly invariable, with up to 95% of patients manifesting some form of pulmonary disease during the course of their lifetime. The natural history of sarcoidosis in the lung is quite variable and spans the spectrum from spontaneous resolution to advanced fibrocystic disease in ~5% of cases. Advanced sarcoidosis will be the subject of this review with a special focus on pulmonary hypertension and lung transplantation as a last-resort treatment option for some patients with end-stage disease.
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