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Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

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Nephrotic Syndrome II : Assessment and Medical Management

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Updated: May 25, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Lymphoplasmacytic lymphoma causing light chain cast nephropathy.

Nuria S Pérez¹, Adriana Garcia-Herrera, Laura Rosiñol

¹Servicio de Nefrología y Trasplante Renal, Hospital Clinic, Barcelona, Spain.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|January 14, 2012

Summary

This study reports the first known case of cast nephropathy in lymphoplasmacytic lymphoma, highlighting the link between light chain deposition and kidney dysfunction. Treatments targeting light chain production are recommended for affected patients.

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Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

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Last Updated: May 25, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

Nephrology
Hematology
Oncology

Background:

Plasma cell dyscrasias often cause kidney disease via monoclonal immunoglobulin production, presenting diverse renal pathologies.
Cast nephropathy on renal biopsy typically indicates myeloma, with rare exceptions involving light chains and lymphoma.

Observation:

This case presents a rare instance of cast nephropathy associated with lymphoplasmacytic lymphoma.
The patient exhibited kidney dysfunction linked to the deposition of pathological light chains.

Findings:

The study identifies lymphoplasmacytic lymphoma as a potential cause of cast nephropathy.
Monoclonal immunoglobulin light chain deposition is confirmed as the mechanism for renal impairment.

Implications:

This finding expands the spectrum of renal manifestations in plasma cell dyscrasias.
Therapeutic strategies aimed at reducing light chain production are suggested for managing associated kidney disease.