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Related Experiment Videos

Metyrapone-induced withdrawal symptoms.

J A Kennedy1, N Hartman, R Sbriglio

  • 1Rockfeller University, New York, New York 10021.

British Journal of Addiction
|September 1, 1990
PubMed
Summary

The metyrapone test can trigger narcotic withdrawal-like symptoms in patients undergoing methadone treatment for opioid dependence. This unexpected response highlights a potential risk for physicians administering the test.

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Area of Science:

  • Endocrinology
  • Addiction Medicine
  • Pharmacology

Background:

  • The metyrapone test assesses hypothalamic-pituitary-adrenal axis function.
  • Its use in studying addictive diseases and opioid dependence is emerging.
  • Metyrapone typically causes mild adverse reactions in non-opiate dependent individuals.

Purpose of the Study:

  • To investigate the effects of the metyrapone test in patients with opioid dependence.
  • To determine if metyrapone administration can induce narcotic withdrawal-like symptoms in this population.

Main Methods:

  • Administered the metyrapone test to 15 former heroin addicts on methadone maintenance or dose reduction.
  • Monitored for narcotic withdrawal-like symptoms post-administration.
  • Included a control group of 9 normal volunteers.

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Main Results:

  • Eight of 15 methadone-maintained patients experienced moderate to severe withdrawal-like symptoms.
  • Four additional patients had mild symptoms.
  • No significant symptoms were observed in 3 methadone patients or any normal volunteers.

Conclusions:

  • Metyrapone administration can induce narcotic withdrawal-like syndromes in individuals dependent on opiates.
  • Physicians should be aware of this potential adverse effect during metyrapone testing.
  • The underlying mechanism for this response remains unknown.