Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypocalcemia in cancer.

E C Abramson1, H Gajardo, S C Kukreja

  • 1Department of Medicine, VA West Side Medical Center, University of Illinois College of Medicine, Chicago 60612.

Bone and Mineral
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of parathyroid hormone related protein, and dihydrotestosterone on proliferation and ornithine decarboxylase mRNA in human prostate cancer cell lines.

International urology and nephrology·2002
Same author

The synthetic phytoestrogen, ipriflavone, and estrogen prevent bone loss by different mechanisms.

Calcified tissue international·1999
Same author

Lifestyle and biologic contributors to proximal femur bone mineral density and hip axis length in two distinct ethnic groups of premenopausal women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·1999
Same author

Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics.

Journal of cellular biochemistry·1999
Same author

[Nutritional status and energy expenditure in elders of differing socioeconomic level].

Revista medica de Chile·1999
Same author

Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats.

The American journal of clinical nutrition·1998
Same journal

Response to letter 'Stereological considerations concerning the measurement of individual osteoid seams and resorption cavities'.

Bone and mineral·1994
Same journal

Gender-related effects of vitamin D metabolites on cartilage and bone.

Bone and mineral·1994
Same journal

Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6.

Bone and mineral·1994
Same journal

Effect of nandrolone decanoate and 1-alpha-hydroxy-calciferol on patients with vertebral osteoporotic collapse. A double-blind clinical trial.

Bone and mineral·1994
Same journal

Basic fibroblast growth factor (BFGF) immunoreactivity as a possible link between head injury and impaired bone fracture healing.

Bone and mineral·1994
Same journal

Assessment of bone density in the distal radius with computer assisted X-ray densitometry (CXD).

Bone and mineral·1994
See all related articles

Hypocalcemia is common in prostate cancer with bone metastases, often due to low albumin or kidney issues. Tumors may also produce factors that stimulate bone to absorb excess calcium, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Endocrinology
  • Biochemistry

Background:

  • Hypocalcemia (low blood calcium) is frequently observed in cancer patients, particularly those with prostate cancer and osteosclerotic bone metastases.
  • In many cases, hypocalcemia is attributed to low serum albumin levels or impaired kidney function.
  • True ionized hypocalcemia can also occur due to chemotherapy toxicity or hyperphosphatemia from tumor lysis syndrome.

Purpose of the Study:

  • To explore the multifaceted causes of hypocalcemia in cancer patients.
  • To investigate the role of tumor-secreted factors in calcium dysregulation.
  • To identify potential therapeutic applications of osteoblast-stimulating factors.

Main Methods:

  • Analysis of total serum calcium levels in cancer patients.

Related Experiment Videos

  • Assessment of serum albumin and renal function.
  • Evaluation of potential links between chemotherapy, tumor lysis, hyperphosphatemia, and ionized hypocalcemia.
  • Investigation of tumor-produced osteoblast-stimulating factors.

    • Main Results:

    • Hypocalcemia is common in prostate cancer with osteosclerotic bone metastases.
    • Low serum albumin and renal failure are frequent contributors to hypocalcemia.
    • Chemotherapy and tumor lysis syndrome can lead to true ionized hypocalcemia.
    • Tumors may secrete factors causing excessive calcium deposition in bone.

    Conclusions:

    • Hypocalcemia in cancer has diverse causes, including nutritional, renal, iatrogenic, and tumor-specific factors.
    • Tumor-derived osteoblast-stimulating factors represent a novel mechanism for calcium dysregulation.
    • These factors hold potential for developing new therapeutic strategies targeting bone metabolism in cancer.