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Updated: May 25, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
[Comparative study between landiolol and amiodarone for therapeutic efficacy after open heart surgery]
Shunichiro Ito1, Taisuke Konishi, Tomohiro Imazuru
1Department of Cardiovascular Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan.
Abstract:
Tachyarrhythmia, especially atrial fibrillation, remains as a common complication after open heart surgery and sometimes leads to fatal condition. Many reports showed that landiolol (ultra short-acting beta one blocker) and amiodarone were effective against postoperative atrial fibrillation (POAF). However, there were few comparative studies between these 2 drugs as prophylactic agents, and no report mentioned the therapeutic efficacy. Our study suggests that landiolol be the 1st choice for rate control of tachyarrhythmia because of easy dose adjustment and mild side effects. Amiodarone may be useful for the patients whose left ventricular function is poor.
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