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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
09:54

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Published on: April 18, 2019

[Stem cell therapy for intractable skin diseases].

Katsuto Tamai1

  • 1Stem Cell Therapy Science, Graduate School of Medicine, Osaka University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 17, 2012
PubMed
Summary

Bone marrow mesenchymal stem cells (MSCs) show promise for treating epidermolysis bullosa (EB), a genetic skin disorder. These cells promote wound healing and correct basement membrane defects in EB models.

Area of Science:

  • Regenerative Medicine
  • Dermatology
  • Stem Cell Biology

Context:

  • Epidermolysis bullosa (EB) is a severe genetic blistering skin disease.
  • Current treatments for EB are limited and focus on symptom management.
  • Bone marrow cells have previously been shown to contribute to skin structure.

Purpose:

  • To review the therapeutic potential of bone marrow mesenchymal stem cells (MSCs) for epidermolysis bullosa (EB).
  • To summarize recent advancements and future directions in MSC-based therapies for EB.
  • To highlight the role of specific bone marrow cell populations in skin repair.

Summary:

  • Bone marrow transplantation in mouse models of EB promotes skin wound healing and corrects basement membrane defects.
  • Epithelial progenitor cells in mouse bone marrow are identified as nonhematopoietic, platelet-derived growth factor receptor-alpha (PDGFRα)-positive mesenchymal stem cells (MSCs).

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Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
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Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

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Last Updated: May 25, 2026

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09:54

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

  • This review consolidates current knowledge on bone marrow MSC therapy for EB.

    • Impact:

    • Bone marrow MSCs offer a potential cell-based therapy for EB, addressing the underlying genetic defect.
    • Understanding the specific MSC population involved can refine therapeutic strategies.
    • This research paves the way for novel treatments for this debilitating skin condition.