[Recent advances of transplantation from bone marrow derived stem cells]

The current progress of blood and marrow transplantation (except CBSCT) could be summarized as the followings; (1) HLA 1-haplo mismatched family donors have been recognized as suitable donor candidates under certain preconditioning regimens. On the other hand, the analysis of the relationship between HLA allele level match/mismatch and the outcomes of the unrelated bone marrow transplantation offered more sophisticated algorithm for donor selection. New devices and drugs to harvest stem cells are under clinical studies. The efficacy of intra bone marrow transplantation has been proved. (2) Fludarabine and i.v. busulfan has one of standards of preconditioning. New generation of drugs such as imatinib may be also beneficial to transplant outcome. (3) ATG, foscavil and other new drugs as well ex vivo manipulated DLI would contribute better outcomes. (4) Registration and follow up for patients and donors would be a global standard in near future.