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Updated: May 25, 2026

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
[Strategy of surgical treatment for ischemic heart disease]
1Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University.
Abstract:
The efficacy of regenerative cell therapy as strategy of cardiac functional recovery in patients with end-stage heart failure has been recently reported, and clinical applications of autologous skeletal myoblast cell transplantation has been already started in Europe and U.S. We developed cell-sheet technology with a temperature-responsive culture dish, which enabled cell-to-cell junction to retain, and started a clinical study of cardiac regenerative therapy using autologous skeletal myoblast cell sheet implantation.
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