Related Experiment Video
Updated: May 25, 2026
14:53
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
Published on: June 26, 2020
[Bone marrow stem cell therapy for stroke].
1Division of Rehabilitation, Sapporo Medical University Hospital.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 17, 2012
Summary
This study found that infusing autologous mesenchymal stem cells (MSCs) into stroke patients was safe and feasible. Further research is warranted to explore if this cell therapy can improve functional recovery after a stroke.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Cell Therapy
Context:
- Stroke is a leading cause of long-term disability.
- Current treatments for stroke are limited, especially for improving functional recovery.
- Mesenchymal stem cells (MSCs) show promise in preclinical models of central nervous system (CNS) diseases.
Purpose:
- To assess the feasibility and safety of using autologous serum-expanded MSCs for stroke patients.
- To evaluate potential adverse effects of MSC transplantation in stroke survivors.
Summary:
- Twelve stroke patients received intravenous infusions of cryopreserved, autologous MSCs.
- Patients were monitored for safety and adverse events post-infusion.
- No severe cell-related adverse effects were observed during serial evaluations.
Impact:
- Intravenous administration of autologous MSCs appears feasible and safe in stroke patients with cerebral infarcts.
- This approach warrants further investigation as a potential therapeutic strategy to enhance functional recovery.
- Establishes a foundation for future clinical trials exploring MSCs in stroke rehabilitation.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...