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Updated: May 1, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 4, 2017
[Protective effect of purslane in a rat model of ulcerative colitis]
1Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. huangyun9@126.com
Objective:
To evaluate the protective effect of purslane on the acute injury caused by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS) in rats.
Method:
Seventy-two male SD rats were separated into 6 groups randomly. Rat model of ulcerative colitis was established by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS). Purslane (2.5, 5, 10 g x kg(-1)) and sulfasalazine(0.5 g x kg(-1)) was administered by enemata, 3 days after TNBS instillation and daily during 10 days before killing the rats. Colons were removed for histological analysis and measurement of myeloperoxidase (MPO).
Result:
Rats treated with purslane (5 and 10 g x kg(-1)) were significantly healthier than TNBS-alone rats, as shown by improved food intake and reduced diarrhea, corrected the disorders in morphology associated to lesions, significantly reduced myeloperoxidase (MPO) levels.
Conclusion:
purslane exerts protective effect in experimental colitis, the effect seems to be related to relieving inflammatory reaction and repairing lesions.
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