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Fractional systolic and diastolic pressures act as predictors of coronary artery disease

Guo-Qiang Gu1, Wei Cui, Xia Feng

  • 1Department of Cardiology, The Second Hospital of Hebei Medical University, Hebei Province, 215 Hepingxi Road,Shijiazhuang, China.

Blood Pressure
|January 17, 2012
PubMed

Insights

Fractional systolic/diastolic pressures in the ascending aorta are strong predictors of coronary artery disease extent. Central aortic pressures are more effective than peripheral pressures for evaluating coronary artery disease severity.

Area of Science:

  • Cardiovascular Medicine
  • Diagnostic Imaging
  • Hemodynamics

Background:

  • Coronary artery disease (CAD) diagnosis relies on various factors.
  • Assessing the extent of CAD is crucial for effective treatment planning.
  • Predictive markers for CAD severity are continuously sought.

Purpose of the Study:

  • To investigate the predictive value of fractional systolic/diastolic pressures for the extent of coronary artery disease.
  • To compare the efficacy of central aortic pressures versus peripheral pressures in evaluating CAD.

Main Methods:

  • A study involving 545 patients (305 men, 240 women, mean age 54.2 years) with confirmed coronary and non-coronary artery disease via angiography.
  • Measurement of brachial and ascending aortic pressures, including fractional systolic/diastolic pressures.
  • Correlation analysis with the number of diseased vessels and Gensini score.

Main Results:

  • Significant differences in blood pressures were observed between patients with and without CAD.
  • Ascending aortic fractional systolic/diastolic pressures correlated with the Gensini score and the number of diseased vessels.
  • Brachial artery pressure was higher than ascending aortic pressure.

Conclusions:

  • Fractional systolic and diastolic pressures in the ascending aorta are robust predictors of CAD extent.
  • Invasive central aortic pressure measurements are superior to peripheral pressures for CAD evaluation.
Abstract

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