Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinically significant change: practical indicators for evaluating psychotherapy outcome.

Psychotherapy research : journal of the Society for Psychotherapy Research·2012
Same author

Immunological profile in primary Sjögren syndrome: clinical significance, prognosis and long-term evolution to other auto-immune disease.

Autoimmunity reviews·2010
Same author

[Retroperitoneal fibrosis and multiple myeloma: fortuitous association?].

La Revue de medecine interne·2010
Same author

[Asthenia, fever, jaundice in a 59-year-old man].

La Revue de medecine interne·2010
Same author

[Dual diagnosis psychosis and substance use disorders in adolescents--part 1].

Fortschritte der Neurologie-Psychiatrie·2010
Same author

[Dual diagnosis psychosis and substance use disorders in adolescents--part 2].

Fortschritte der Neurologie-Psychiatrie·2010

Related Experiment Videos

Assessing clinical significance: proposed extensions to method.

R Tingey1, M Lambert, G Burlingame

  • 1a V.A. Medical Center , Drew University , Long Beach.

Psychotherapy Research : Journal of the Society for Psychotherapy Research
|January 17, 2012
PubMed
Summary
This summary is machine-generated.

This study refines clinical significance assessment in psychotherapy outcome research by addressing limitations in Jacobson and Revenstorf's method. It proposes extensions for deriving and validating normative samples, enhancing reliable change estimates.

Related Experiment Videos

Area of Science:

  • Psychology
  • Clinical Psychology
  • Psychotherapy Research

Background:

  • Jacobson, Follette, and Revenstorf's (1984) method established a convention for assessing clinical significance in psychotherapy.
  • Existing limitations in this method (Jacobson & Revenstorf, 1988) require refinement for accurate outcome evaluation.

Purpose of the Study:

  • To address limitations in the operationalization of social validation methodology for normative samples.
  • To propose extensions and guidelines for specifying, validating, and expanding normative samples for clinical significance assessment.
  • To enhance the utility and application of clinical significance measures in psychotherapy research.

Main Methods:

  • A psychometric approach was used to develop extensions based on the Symptom Checklist 90-R.
  • Reliable change estimates and cutoff scores were applied from a clinician's perspective.
  • Outcome data from four therapy patients were analyzed to demonstrate the proposed extensions.

Main Results:

  • The study identified limitations in deriving and applying normative standards for clinical significance.
  • Proposed extensions offer guidelines for improved specification and validation of normative samples.
  • Application to patient data illustrated the practical utility of the enhanced methods for assessing reliable change.

Conclusions:

  • The proposed extensions enhance the rigor and applicability of clinical significance assessment in psychotherapy.
  • Refined methods improve the ability to determine meaningful treatment outcomes.
  • The study contributes to more precise and reliable evaluation of therapeutic progress.