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Updated: May 25, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
Pattern-recognition receptors in human eosinophils.
Anne Månsson Kvarnhammar1, Lars Olaf Cardell
1Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. anne.mansson.kvarnhammar@ki.se
Pattern-recognition receptors (PRRs) on eosinophils recognize pathogens and danger signals, initiating immune responses. These receptors are crucial in fighting infections and modulating allergic and tumor immunity.
Area of Science:
- Immunology
- Cell Biology
Background:
- Pattern-recognition receptors (PRRs) are key in innate immunity, detecting microbial and danger signals.
- Eosinophils are versatile immune cells implicated in parasitic infections, allergies, and cancer immunity.
Purpose of the Study:
- To investigate the expression and function of PRRs in human eosinophils.
- To understand the role of eosinophil PRRs in immune responses and disease pathogenesis.
Main Methods:
- Analysis of human eosinophil expression of various PRRs, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and C-type lectin receptors (CLRs).
- Review of literature on PRR stimulation effects on eosinophil functions like survival, oxidative burst, and mediator release.
Main Results:
- Human eosinophils express a broad range of PRRs (e.g., TLR1-5, TLR7, TLR9, NOD1, NOD2, Dectin-1, RAGE).
- Stimulation of these PRRs triggers eosinophil survival, oxidative burst, adhesion, and release of cytokines, chemokines, and cytotoxic proteins.
- Eosinophils modulate immune responses through interactions with other cells.
Conclusions:
- Eosinophils, equipped with diverse PRRs, are involved in defense against helminths, bacteria, viruses, and fungi.
- Eosinophil PRRs play significant roles in allergic diseases and cancer immunity, influencing disease exacerbation and tumor growth.
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