Multiple myeloma in a mink handler following exposure to Aleutian disease
Abstract:
Aleutian disease of mink is a viral illness characterized by systemic plasmocytosis and hypergammaglobulinemia. Some affected mink develop a monoclonal gammaglobulin spike and Bence-Jones proteinuria. A case of multiple myeloma in a mink handler with a 15-year history of exposure to Aleutian mink is presented. Previously reported cases of possible Aleutian disease (AD) in man are discussed and the pathogenesis of AD reviewed. Aleutian disease virus (ADV) may produce asymptomatic infection in exposed individuals. Available data suggest symptomatic disease in humans is extremely rare.
Insights
Aleutian disease of mink, a viral illness, can infect humans. While symptomatic human disease is rare, this case highlights potential risks for those with prolonged exposure to infected mink.
Area of Science:
- Veterinary Virology
- Human Infectious Diseases
- Immunology
Background:
- Aleutian disease of mink is a viral illness caused by the Aleutian disease virus (ADV).
- It is characterized by systemic plasmacytosis and hypergammaglobulinemia in mink.
- Some mink develop monoclonal gammaglobulin spikes and Bence-Jones proteinuria.
Observation:
- A case of multiple myeloma is presented in a human handler with a 15-year history of exposure to Aleutian mink.
- Previously reported cases of possible Aleutian disease in humans are discussed.
Findings:
- Aleutian disease virus (ADV) can cause asymptomatic infections in exposed humans.
- Symptomatic disease in humans appears to be extremely rare.
Implications:
- This case underscores the potential zoonotic transmission of ADV.
- Further research into ADV pathogenesis and human health risks is warranted.
- Clinicians should consider ADV exposure in differential diagnoses for B-cell disorders in individuals with occupational exposure to mink.
