Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 25, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Enamel alterations in serotonin 2B receptor knockout mice.

Yassine Harichane¹, Sasha Dimitrova-Nakov, Arnaud Marchadier

¹INSERM, UMR-S 747, F-75006, Paris, France.

European Journal of Oral Sciences

|January 17, 2012

Summary

The serotonin 2B receptor (5-HT(2B) R) is crucial for tooth enamel development. Knockout mice lacking this receptor showed significantly reduced enamel volume and structural defects, impacting mineralization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cousin Syndrome Due to TBX15 Gene Variants: Three Novel Cases and Review of the Literature.

Clinical genetics·2026

Same author

Identification of an episignature for CHD3-related Snijders Blok-Campeau syndrome reveals heterogeneity in the CHARGE syndrome episignature: towards a better characterisation of chromatinopathies.

Genome medicine·2026

Same author

[ADAM10 and ADAM17 proteases: new players in the controlled release of extracellular vesicles].

Medecine sciences : M/S·2026

Same author

More on bone microarchitecture and volumetric BMD in men and women with PLS3 gene variants assessed with HR-pQCT.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025

Same author

Relative exchangeable copper: A highly specific and sensitive biomarker for Wilson disease diagnosis.

JHEP reports : innovation in hepatology·2025

Same author

ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane.

Journal of extracellular vesicles·2025

Area of Science:

Biochemistry
Developmental Biology
Dental Research

Background:

The serotonin 2B receptor (5-HT(2B) R) is implicated in various physiological processes.
Its specific role in tooth enamel formation and mineralization remains largely unexplored.

Purpose of the Study:

To investigate the function of the 5-HT(2B) R in enamel formation and mineralization.
To compare enamel characteristics in 5-HT(2B) R knockout (KO) mice with wild-type (WT) mice.

Main Methods:

Micro-computed tomography (micro-CT) imaging for quantitative enamel volume analysis.
Energy-dispersive X-ray microanalysis to assess mineralization.
Scanning electron microscopy (SEM) to examine enamel microstructure.

Main Results:

More Related Videos

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

Related Experiment Videos

Last Updated: May 25, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

KO mice exhibited significantly reduced enamel volume in molars compared to WT mice.
Defective mineralization and structural abnormalities, including altered Hunter-Schreger bands, were observed in KO mice.
Minor disturbances were also noted in the incisors of KO mice.

Conclusions:

The 5-HT(2B) R plays a significant role in regulating enamel formation and mineralization.
Disruption of 5-HT(2B) R signaling impairs ameloblast function and amelogenesis.
These findings highlight the importance of 5-HT(2B) R in maintaining healthy tooth enamel structure.