Related Experiment Video
Updated: May 25, 2026
08:32
Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Impedance nadir values correlate with barium bolus amount
1Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA. h_imam@hotmail.com
Summary
Impedance monitoring accurately measures esophageal bolus volume, correlating well with videoesophagram findings. This technique effectively identifies abnormal bolus transit, including failed clearing, reflux, and esophageal escape.
Area of Science:
- Gastroenterology
- Medical Imaging
- Physiology
Background:
- Esophageal bolus transit assessment is crucial for diagnosing swallowing disorders.
- Videoesophagram is a standard method, but impedance monitoring offers a non-radiographic alternative.
Purpose of the Study:
- To evaluate the accuracy of impedance monitoring in quantifying esophageal bolus volume compared to videoesophagram.
- To correlate impedance values with barium area and identify causes of abnormal bolus transit.
Main Methods:
- Simultaneous impedance-manometry-videoesophagram was performed on 80 subjects swallowing barium-saline boluses.
- Impedance falls below 1000 ohms were analyzed and correlated with videofluoroscopic findings of barium presence and area.
Main Results:
- A strong correlation (r=0.83, P<0.001) was found between impedance nadir values and barium area.
- 97% of impedance falls indicated barium presence, consistent across failed clearing, reflux, and esophageal escape.
- Low impedance nadir values (<400 ohms) corresponded to large barium areas, indicating significant bolus volume.
Conclusions:
- Impedance monitoring is a valuable tool for assessing esophageal bolus volume and transit.
- The technique reliably detects abnormal bolus transit, providing quantitative data comparable to videoesophagram.
Related Concept Videos
01:23Lower GI Series: Barium Enema
A Barium Enema, or a lower GI series, is a specialized radiographic examination designed to visualize the lower gastrointestinal tract, specifically the colon and rectum. This procedure is instrumental in diagnosing various conditions such as colorectal cancer, polyps, diverticulosis, and inflammatory bowel disease.
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
01:24Upper GI Series: Barium Swallow
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
00:56One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance
Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
01:18Two-Compartment Open Model: IV Bolus Administration
The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
The disparity between drug input and the sum of drug transfer rates between...
01:19One-Compartment Open Model for IV Bolus Administration: General Considerations
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
01:24Bode Plots Construction
The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):