Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
UV–Vis Spectroscopy: Woodward–Fieser Rules01:29

UV–Vis Spectroscopy: Woodward–Fieser Rules

UV–Visible absorption spectra of conjugated dienes arise from the lowest energy π → π* transitions. The light-absorbing part of the molecule is called the chromophore, and the substituents directly attached to the chromophore are called auxochromes. A strong correlation exists between the absorption maxima, λmax, and the structure of a conjugated π system. The Woodward–Fieser rules predict the value of λmax for a given structure by adding the contributions...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemotherapy With or Without Anti-EGFR Agents in Left- and Right-Sided Metastatic Colorectal Cancer: An Updated Meta-Analysis.

Journal of the National Comprehensive Cancer Network : JNCCN·2019
Same author

Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes.

Nucleic acids research·2019
Same author

Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3β signaling.

Cancer science·2019
Same author

MSI2-TGF-β/TGF-β R1/SMAD3 positive feedback regulation in glioblastoma.

Cancer chemotherapy and pharmacology·2019
Same author

METTL3 facilitates tumor progression via an m<sup>6</sup>A-IGF2BP2-dependent mechanism in colorectal carcinoma.

Molecular cancer·2019
Same author

Association between suicide and multiple sclerosis: An updated meta-analysis.

Multiple sclerosis and related disorders·2019

Related Experiment Video

Updated: May 25, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
07:16

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC

Published on: February 2, 2024

2-(2-phenylethyl)chromones from Chinese eaglewood.

Lin Yang1, Lirui Qiao, Dan Xie

  • 1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.

Phytochemistry
|January 17, 2012
PubMed
Summary

Compounds from Chinese eaglewood demonstrated neuroprotective effects. One compound significantly protected against glutamate and corticosterone-induced neurotoxicity in cell models, enhancing cell viability.

Related Experiment Videos

Last Updated: May 25, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
07:16

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC

Published on: February 2, 2024

Area of Science:

  • Natural Products Chemistry
  • Neuropharmacology

Background:

  • Chinese eaglewood is a traditional medicinal resource.
  • Chromone derivatives are known for diverse biological activities.

Purpose of the Study:

  • To isolate and characterize compounds from Chinese eaglewood.
  • To evaluate the neuroprotective potential of isolated compounds.

Main Methods:

  • Ethanolic extraction of Chinese eaglewood.
  • Structure elucidation using spectroscopic analyses.
  • Assessment of neurotoxicity in P12 pheochromocytoma and U251 glioma cell lines.

Main Results:

  • Two 2-(2-phenylethyl) chromones and one 2-(2-phenylethenyl) chromone were isolated.
  • One isolated compound exhibited significant neuroprotection against glutamate-induced neurotoxicity (82.2% cell viability).
  • The same compound showed strong protection against corticosterone-induced neurotoxicity (86.9% cell viability) at 10 μM.

Conclusions:

  • Chinese eaglewood contains bioactive chromone compounds.
  • A novel chromone derivative possesses significant neuroprotective properties.
  • This compound shows potential for therapeutic development against neurodegenerative conditions.