Related Experiment Video

Updated: May 25, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

Clinical and laboratory characteristics of children positive for antiphospholipid antibodies

Paola Giordano1, Riccardina Tesse, Giuseppe Lassandro

  • 1Department of Biomedicine of Developmental Age, University of Bari, Bari, Italy. giordano@bioetaev.uniba.it

Blood Transfusion = Trasfusione Del Sangue
|January 17, 2012
PubMed

Insights

Children with antiphospholipid antibodies (aPL) show varied clinical features. Persistent aPL positivity is linked to higher thrombotic event rates, suggesting distinct criteria for pediatric antiphospholipid syndrome (APS).

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Hematology

Background:

  • Standardized criteria for pediatric antiphospholipid syndrome (APS) are lacking, making prevalence estimation challenging.
  • Antiphospholipid antibodies (aPL) in children present heterogeneous clinical and laboratory features.
  • This study investigates clinical and laboratory characteristics of children with aPL.

Purpose of the Study:

  • To assess clinical and laboratory characteristics of children with antiphospholipid antibodies (aPL).
  • To contribute to understanding heterogeneous aPL-related features in childhood.
  • To inform the development of classification criteria for pediatric APS.

Main Methods:

  • Forty-four pediatric patients with prolonged activated partial thromboplastin time were enrolled.
  • Patients were categorized into transiently positive (Group I) or persistently positive (Group II) for aPL based on antibody detection over at least 12 weeks.
  • Standard procedures were used to detect lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI) antibodies. Clinical history and symptoms were recorded.

Main Results:

  • Group II (persistently positive) had a higher rate of thrombotic events (36%) compared to Group I (transiently positive).
  • Persistently positive patients showed a significantly higher prevalence of anticardiolipin (aCL) antibodies, specifically aCL IgG and anti-β2GPI IgM subtypes.
  • While LA positivity rates were similar, specific aPL subtypes differed significantly between transient and persistent groups.

Conclusions:

  • Pediatric patients with antiphospholipid antibodies exhibit diverse clinical and laboratory profiles.
  • Persistent aPL positivity is associated with an increased risk of thrombotic events and specific antibody subtypes.
  • Findings underscore the need for distinct classification criteria for pediatric antiphospholipid syndrome (APS).
Abstract

More Related Videos

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...