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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Reactions02:06

Allergic Reactions

Overview
Cross-reactivity00:42

Cross-reactivity

Overview

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Related Experiment Video

Updated: May 25, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Alternative and complementary treatment for food allergy.

Julia Ann Wisniewski1, Xiu-Min Li

  • 1Department of Pediatrics, Division of Allergy and Immunology, University of Virginia, 409 Lane Road, Box 801355, Charlottesville, VA 22908, USA. jaw4he@virginia.edu

Immunology and Allergy Clinics of North America
|January 17, 2012
PubMed
Summary

Consumer interest in complementary and alternative medicine (CAM) for food allergy is growing, but evidence for efficacy and safety is limited. FAHF-2 is the only herbal treatment validated in human trials for food allergy.

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Area of Science:

  • Integrative medicine
  • Allergy research
  • Pharmacology

Background:

  • Growing consumer interest in complementary and alternative medicine (CAM) for food allergy treatment.
  • Limited understanding of the clinical efficacy, mechanisms, and safety of most CAM therapies for food allergy.
  • Need for evidence-based evaluation of CAM interventions in food allergy management.

Purpose of the Study:

  • To review recent advances in CAM for food allergy.
  • To explore novel treatment approaches and their mechanisms of action.
  • To highlight the current status of investigational CAM therapies.

Main Methods:

  • Literature review of recent advances in CAM for food allergy.
  • Focus on acupuncture, herbal medicine, probiotics, and alternative allergen immunotherapy.
  • Review of mechanisms of action for novel treatment approaches.

Main Results:

  • Several novel CAM approaches for food allergy are under investigation.
  • FAHF-2 identified as the sole investigational herbal formulation validated in human clinical trials.
  • Mechanisms of action for some novel approaches are reviewed.

Conclusions:

  • Significant knowledge gaps exist regarding CAM efficacy and safety in food allergy.
  • FAHF-2 represents a promising, clinically validated herbal option for food allergy.
  • Further research is needed to validate other CAM therapies for food allergy treatment.