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Updated: May 25, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Effect of fluid collections on long-term outcome after lower limb amputation
Rajiv Singh1, Guruprasad Venkateshwara
1Osborn Neurorehabilitation Unit, Northern General Hospital, Sheffield, United Kingdom. rajiv.singh@sth.nhs.uk
Objective:
To ascertain the long-term outcome for individuals found to have fluid collections in residual limbs after amputation.
Design:
Prospective cohort study.
Setting:
Outpatient follow-up at a prosthetic rehabilitation unit.
Participants:
Successive lower limb amputations (N=105) scanned for fluid collections after operation and followed up after 3 years.
Interventions:
Not applicable.
Main Outcome Measures:
Survival; secondary outcomes of prosthetic limb use, hours of prosthetic limb-wearing, anxiety and depression levels.
Results:
After 3 years, 70 individuals were alive, of whom 21 (30%) had fluid collections originally. There was no significant difference at follow-up between the group that had fluid collections in their residual limbs after surgery and the group that did not in terms of survival (χ(2)(1)=.21, P=.64), numbers wearing prosthetic limb (χ(2)(1)=.102, P=.75), hours of limb wearing (t(37)=.35, P=.72), anxiety (χ(2)(1)=.77, P=.78), and depression (χ(2)(1)=1.98, P=.16). A multivariable logistic regression confirmed that presence of fluid collection was not associated with survival.
Conclusions:
Fluid collections in residual limbs after amputation are common, but patients can be reassured that their long-term outcomes are not affected.
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