Related Experiment Video
Updated: May 25, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Malignant glioma grade 3 and 4: how relevant is timing of radiotherapy?
Friederike M Wehming1, Bettina Wiese, Makoto Nakamura
1Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany.
Aims And Background:
The aim of this study is to determine prognostic factors that influence further outcome in patients with glioma.
Methods:
Between 01/2002 and 08/2008, 153 patients with malignant gliomas of WHO-grade 3 or 4 who were treated with external beam radiotherapy with or without chemotherapy.
Results:
In univariate analysis, following factors were ascertained as statistically significant prognostic parameters: grade (p = 0.000), time between operation and radiotherapy >24 days (p = 0.044) for progression-free survival; grade (p = 0.000), age<58 years (p = 0.001), extent of surgery (p = 0.011), time between operation and radiotherapy >24 days (p = 0.009), overall treatment time >68 days (p = 0.003), use of chemotherapy (p = 0.015) for overall survival. A longer time period between resection and start of radiotherapy showed to be associated with improved outcome. After multivariate analysis, only grade (p = 0.000) remained a statistically significant factor for progression-free and grade (p = 0.000) and use of chemotherapy (p = 0.031) for overall survival.
Conclusions:
We were able to recognize grade and use of chemotherapy as statistically significant prognostic determinants, but not time intervals or overall treatment time.
