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Updated: May 25, 2026

Microcrystal Electron Diffraction of Small Molecules
Published on: March 15, 2021
Electrons for single molecule diffraction and imaging
Ke Ran1, Jian-Min Zuo, Qing Chen
1Department of Material Science and Engineering and Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Abstract:
We demonstrate the potential of electrons for single molecule diffraction and imaging using C₆₀ molecules confined inside single-walled carbon nanotubes (C₆₀s@SWCNT or peapod) as a model system. A 25 nm diameter electron beam from a field emission gun source is used to record diffraction patterns from individual peapods using imaging plates. The electron beam illuminates about 25 C₆₀ molecules. Experimentally, we found that the molecules diffract inside ∼15% of the host nanotubes. With the help of simulations, we explore the limits of electron molecular diffraction and its sensitivity to the molecular configurations. We show that the combination of electron diffraction and electron direct imaging provides the best approach to single molecule imaging.
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