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Related Experiment Videos

Urinary tissue factor activity in colorectal disease.

N Carty1, I Taylor, O S Roath

  • 1University of Surgical Unit, General Hospital, Southampton, UK.

The British Journal of Surgery
|October 1, 1990
PubMed
Summary

Urinary procoagulant activity (PCA), linked to tissue factor (TF), is elevated in colorectal cancer and inflammatory bowel disease. This finding suggests urinary TF may serve as a valuable screening tool for these conditions.

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Area of Science:

  • Biochemistry
  • Oncology
  • Urology

Background:

  • Procoagulant activity (PCA) is known in normal urine.
  • Tissue factor (TF) is implicated in various cancers and inflammatory conditions.
  • Urinary TF levels in cancer patients have not been previously studied.

Purpose of the Study:

  • To investigate urinary PCA levels in patients with colorectal cancer and inflammatory bowel disease.
  • To determine if urinary TF can serve as a diagnostic marker for these conditions.
  • To explore the role of TF in abnormal hemostasis associated with malignancy.

Main Methods:

  • Measurement of urinary PCA in hospital controls, patients with rheumatoid arthritis, inflammatory bowel disease, colorectal cancer, and those undergoing colonoscopy.
  • Utilized TF inhibitors to confirm the nature of PCA.

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  • Employed Western blotting to determine the molecular weight of urinary TF.

    • Main Results:

    • Urinary PCA was significantly higher in patients with colorectal cancer and inflammatory bowel disease compared to controls and rheumatoid arthritis patients.
    • A high percentage of colonoscopy patients with subsequent diagnoses of carcinoma or inflammatory bowel disease showed elevated urinary PCA levels.
    • Western blotting confirmed a urinary TF molecular weight of approximately 38,000.

    Conclusions:

    • Elevated urinary PCA, specifically TF, is associated with colorectal cancer and inflammatory bowel disease.
    • Urinary TF determination shows potential as a non-invasive screening test for patients undergoing colonoscopy.
    • These findings support the link between abnormal hemostasis and malignancy.