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Updated: May 25, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Endodontic management in a patient with vitamin D-resistant Rickets.

Charalampos Beltes1, Evanthia Zachou

  • 1Department of Endodontics, Aristotle University, School of Dentistry, Thessaloniki, Greece. beltes@dent.auth.gr

Journal of Endodontics
|January 17, 2012
PubMed
Summary

Early endodontic treatment and continuous monitoring can significantly improve dental health in children with hypophosphatemic vitamin D-resistant rickets (VDRR). This approach aids bone reconstruction and resolves oral manifestations of the disease.

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Area of Science:

  • Endocrinology
  • Pediatric Dentistry
  • Metabolic Bone Diseases

Background:

  • Hypophosphatemic vitamin D-resistant rickets (VDRR) is a genetic disorder affecting phosphate and calcium metabolism.
  • VDRR disrupts bone and dentin mineralization, leading to systemic and oral health issues in growing individuals.

Observation:

  • A 15-year-old patient with VDRR presented with unexplained periapical lesions.
  • Radiographic analysis revealed characteristic dental anomalies including short roots, enlarged pulp chambers, thin enamel/dentin, and irregular lamina dura.

Findings:

  • Conservative endodontic treatment was performed on teeth with pulp necrosis and periapical lesions.
  • Follow-up radiographs at 6 months, 1 year, and 2 years demonstrated progressive bone healing and reconstruction without clinical symptoms.

Implications:

  • Early diagnosis and conventional endodontic intervention are crucial for managing dental complications in VDRR patients.
  • Regular radiographic monitoring is essential for assessing treatment efficacy and bone regeneration in VDRR-affected dentition.