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Published on: March 30, 2019
Meta-analysis for cyclin E in lung cancer survival
Li-nian Huang1, Dong-sheng Wang, Yu-qing Chen
1Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Provincial Key Laboratory of Clinical Basic Research on Respiratory Disease, Bengbu, Anhui, China. bbmchln@126.com
Cyclin E overexpression is a significant predictor of poor survival in lung cancer (LC) patients. This finding holds true for non-small cell lung cancer (NSCLC) and adenocarcinoma subtypes.
Area of Science:
- Oncology
- Molecular Biology
- Biomarkers
Background:
- Lung cancer (LC) remains a leading cause of cancer mortality worldwide.
- Identifying reliable prognostic markers is crucial for patient management and treatment strategies.
Purpose of the Study:
- To evaluate the prognostic value of cyclin E expression in the survival of lung cancer patients.
- To conduct a systematic review and meta-analysis of existing literature.
Main Methods:
- Systematic literature search of electronic databases up to August 2011.
- Meta-analysis using pooled hazard ratios (HR) and 95% confidence intervals (CI).
- Assessment of heterogeneity and publication bias.
Main Results:
- Fourteen studies comprising 2606 cases were analyzed.
- Cyclin E overexpression significantly predicts poor prognosis in lung cancer patients (HR: 1.38, 95% CI: 1.07-1.79).
- The association was significant in non-small cell lung cancer (NSCLC) and adenocarcinoma (AD), but not squamous cell carcinoma (SQ).
Conclusions:
- Cyclin E overexpression is a validated poor prognostic biomarker in lung cancer.
- Further research may explore therapeutic targeting of cyclin E in specific lung cancer subtypes.
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