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Updated: May 25, 2026

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Published on: June 20, 2020
Quetiapine-induced frequent premature ventricular contraction
Akiko Deguchi1, Masayuki Nakamura, Takehiro Hayashi
1Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, 1-35-8 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan.
Abstract:
A 17-year-old female diagnosed with bipolar II disorder was treated for emotional lability with quetiapine. Two-lead electrocardiography revealed frequent monomorphic premature ventricular contraction (PVC) during an electroencephalography examination. Twenty-four-hour Holter electrocardiography revealed 0.6% uniform frequent PVCs and indicated that the readministration and second-time withdrawal of quetiapine markedly increased (7.1%) and decreased the frequency of PVC (1.1%), respectively. This case indicates that quetiapine can cause PVC as a serious side effect.
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