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Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
Published on: December 20, 2017
Oral biodrug delivery using cell-penetrating peptide
El-Sayed Khafagy1, Mariko Morishita
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Advanced Drug Delivery Reviews
|January 17, 2012
Summary
Cell-penetrating peptides (CPPs) show promise for enhancing oral absorption of biotherapeutics like peptides and proteins. This strategy offers a convenient method for delivering drugs through the intestinal membrane, improving bioavailability.
Area of Science:
- Biotechnology
- Pharmacology
- Drug Delivery Systems
Background:
- Biotherapeutics such as peptides and proteins are crucial for treating diseases but suffer from poor oral absorption due to intestinal barrier limitations.
- Developing effective oral delivery systems for these large molecules is a significant challenge in pharmaceutical research.
Purpose of the Study:
- To explore the potential of cell-penetrating peptides (CPPs) as carriers for enhancing the oral bioavailability of peptide and protein drugs.
- To introduce a vision for CPP-based delivery systems to overcome intestinal permeability barriers for novel biotherapeutics.
Main Methods:
- Review and conceptualization of cell-penetrating peptides (CPPs) like HIV-1 Tat, penetratin, and oligoarginine for drug delivery.
- Focus on the application of CPPs to facilitate the transport of therapeutic macromolecules across the intestinal epithelial membrane.
Main Results:
- CPPs demonstrate potential as effective tools for improving the intestinal absorption of peptides and proteins.
- Coadministration of CPPs with drugs via intermolecular interactions presents a convenient methodology for enhanced oral delivery.
Conclusions:
- Cell-penetrating peptides (CPPs) offer a promising strategy to overcome the low permeability of therapeutic peptides and proteins through the intestinal membrane.
- Further development of CPP-based delivery systems is essential for realizing oral formulations of novel biotherapeutics.
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